Studies on chemical modification of monensin. Part 7: Synthesis and Ca2+ ion transport activity of 25-carboxylmonensin

Autor:	Rie Tanaka, Yukio Ogihara, Hajime Mizukami, Akito Nagatsu, Jinsaku Sakakibara, Masayo Hashimoto
Rok vydání:	2000
Předmět:	Organic Chemistry Monensin Inorganic chemistry Ionophore chemistry.chemical_element Chemical modification Calcium Biochemistry Medicinal chemistry chemistry.chemical_compound chemistry Drug Discovery Molecule Ion transporter Lasalocid
Zdroj:	Tetrahedron Letters. 41:2629-2632
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)00233-1
Popis:	Ionophore antibiotic monensin ( 1 ) was converted to 25-carboxylmonensin ( 3 ), which has two carboxyl groups at both ends of the molecule. Ca 2+ ion transport activity of 25-carboxylmonensin ( 3 ) was evaluated by the CHCl 3 liquid membrane method, and the activity was 3.1 times the value of the calcium ionophore, lasalocid A.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a0a1223b107f9ae730718cd29780a3a0 https://doi.org/10.1016/s0040-4039(00)00233-1 Zobrazit plný text záznamu Full Text from ScienceDirect