Immunological Changes After Both Exercise and Activity in Chronic Fatigue Syndrome

Autor:	David J. Bentley, J.M. Thomas, N. Power, J.M. Parkin, T.M. Yap, A.J. Pinching, Peter D White, Keith E. Nye, Matthew Buckland, Veronica E. Vleck
Rok vydání:	2004
Předmět:	medicine.medical_specialty Neuropsychology and Physiological Psychology business.industry Internal medicine Chronic fatigue syndrome Physical therapy Medicine General Medicine medicine.symptom business medicine.disease Malaise
Zdroj:	Journal of Chronic Fatigue Syndrome. 12:51-66
ISSN:	1547-0660 1057-3321
DOI:	10.1300/j092v12n02_06
Popis:	Background: The chronic fatigue syndrome (CFS) is characterized by post-exertional malaise and fatigue. We designed this pilot study to explore whether the illness was associated with alterations in immunological markers following exercise.Methods: We measured immunological markers before and up to three days after either a sub-maximal or maximal bicycle exercise test. We studied nine patients with CFS and nine age-and sex-matched healthy but sedentary controls. We also studied the same patients with CFS at home after a night's sleep and then after traveling to the study center.Results: There were no significant differences in any of the cell markers after a sub-maximal exercise test compared to a maximal test. However, we found elevated concentrations of plasma transforming growth factor beta (TGF-s), even before exercise, in subjects with CFS (median (IQR) of 904 (182-1072) pg/ml) versus controls (median (IQR) of 50 (45-68) pg/ml) (P < .001). Traveling from home to the hospital significantly ele...
Databáze:	OpenAIRE
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