Sensory Gating in TAAR1 Knockout Mice
| Autor: | A. A. Aleksandrov, E. S. Dmitrieva, V. M. Knyazeva, Y. A. Simon, N. V. Polyakova, L. N. Stankevich, A. Y. Aleksandrov |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Evolutionary Biochemistry and Physiology. 58:979-985 |
| ISSN: | 1608-3202 0022-0930 |
| DOI: | 10.1134/s0022093022040044 |
| Popis: | Abstract Trace amines (TA) are a family of endogenous compounds structurally similar to classical biogenic amines that may be involved in the pathogenesis of a number of neuropsychiatric disorders. One of the most studied and perspective member of the TA associated receptors (TAARs) family is the TAAR1. The aim of the present study was to investigate the sensory gating (SG) in freely moving TAAR1 knockout mice in a chronic experiment. The study of SG was conducted in the paired-click paradigm. The SG indices were calculated as an absolute value by subtracting the second stimulus response amplitude from the first stimulus response amplitude (S1–S2) and as a relative value calculated by dividing the S2 amplitude by the response amplitude on S1 (S2/S1). As a result, a significant decrease in the amplitude of the N40 component was found in TAAR1 knockout mice compared to wild-type mice. In addition, the absolute value of sensory gating calculated by the S1–S2 method was also reduced, but the relative value of sensory gating denoted as S1/S2 ratio remained unchanged. Thus, the data obtained indicate the involvement of TAAR1 in the generation of auditory evoked potentials and the potential involvement of the trace amine system in the dosing and filtering of sensory information. |
| Databáze: | OpenAIRE |
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