Curative Potentials of Garlic (Allium sativum) Extract against Di-(2-Ethylhexyl) Phthalate Induced Reproductive Toxicity in Female Mice

Autor: null Sajida Batool, null Riqza Aziz, null Sitara Shameem, null Marrium Shaheen, null Saira Batool, null Iqra Aslam, null Fatima Iram
Rok vydání: 2022
Předmět:
Zdroj: Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences. 59:39-53
ISSN: 2518-427X
2518-4261
DOI: 10.53560/ppasb(59-3)720
Popis: The present study was intended to find out the curative potentials of Garlic (Allium sativum) against di-(2-Ethylhexyl) phthalate (DEHP) induced toxicity in the reproductive system of female mice. Forty female mice were divided into four groups (n=10) as the (a) control group was given normal feed and drinking water, (b) aqueous garlic extract treated group (500 mg/kg), (c) DEHP group received 500 mg/kg in corn oil, and (d) DEHP + aqueous garlic extract each at a dosage of 500 mg/kg body weight. All treatments were given daily through oral gavage for 28 days. After completion of the experiment, all the animals were dissected through cervical dislocation to get reproductive organs. Collected organs were weighed and processed through the conventional histology technique of staining with eosin and hematoxylin. This study indicated that DEHP exposure caused a significant decrease (P
Databáze: OpenAIRE