A Short and Practical Synthesis of 1-Deoxynojirimycin

Autor:	Richard M. Weier, Medich John R, James R. Behling, Ish K. Khanna, Mike G. Scaros, Payman Farid, Michael Lee Prunier
Rok vydání:	1991
Předmět:	chemistry.chemical_compound Chemistry Intramolecular force Glucosidase Inhibitor Organic Chemistry Organic chemistry Protecting group 1-Deoxynojirimycin Reductive amination Acetonide
Zdroj:	Synthetic Communications. 21:1383-1386
ISSN:	1532-2432 0039-7911
Popis:	The potent glucosidase inhibitor 1-deoxynojirimycin was synthesized from L-sorbose using a short synthesis and only one protecting group. The last step, which constituted the removal of an acetonide protecting group and an intramolecular reductive amination, was accomplished on an acidic lon-exchange resin. This provided a synthesis capable of being operated on a multi-kilogram scale.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a07f24b47c451bb4d4b4eff6c7bba1b7 https://doi.org/10.1080/00397919108021285 Zobrazit plný text záznamu