A Short and Practical Synthesis of 1-Deoxynojirimycin
Autor: | Richard M. Weier, Medich John R, James R. Behling, Ish K. Khanna, Mike G. Scaros, Payman Farid, Michael Lee Prunier |
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Rok vydání: | 1991 |
Předmět: | |
Zdroj: | Synthetic Communications. 21:1383-1386 |
ISSN: | 1532-2432 0039-7911 |
Popis: | The potent glucosidase inhibitor 1-deoxynojirimycin was synthesized from L-sorbose using a short synthesis and only one protecting group. The last step, which constituted the removal of an acetonide protecting group and an intramolecular reductive amination, was accomplished on an acidic lon-exchange resin. This provided a synthesis capable of being operated on a multi-kilogram scale. |
Databáze: | OpenAIRE |
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