Expression of T-cell-associated antigens in B-cell non-Hodgkin's lymphoma
| Autor: | Tohru Inaba, Kenhiro Rin, Noboru Yamagata, Eishi Ashihara, Akira Okano, Shigeyoshi Hibi, Akio Okamoto, Ryoichi Takahashi, Chihiro Shimazaki, Manabu Yoshimura, Naohisa Fujita, Masao Nakagawa, Mayumi Hatsuse, Toshiya Sumikuma, Yoshikazu Sudo, Satoshi Murakami |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry T cell Hematology medicine.disease Non-Hodgkin's lymphoma Lymphoma International Prognostic Index medicine.anatomical_structure Immunophenotyping immune system diseases hemic and lymphatic diseases medicine CD5 Extranodal Involvement business B cell |
| Zdroj: | British Journal of Haematology. 109:592-599 |
| ISSN: | 0007-1048 |
| DOI: | 10.1046/j.1365-2141.2000.02006.x |
| Popis: | We performed the immunophenotyping of 101 patients with B-cell non-Hodgkin's lymphoma (B-NHL) using two-colour flow cytometry (FCM) and found that lymphoma cells coexpressed at least one kind of T-cell-associated antigen (T-Ag; CD2, CD5, CD7) in 25 patients (24. 8%). Among these three T-Ags, CD5 was the most frequently expressed, in 21 patients (20.8%), followed by CD7, expressed in five patients (5.0%), and CD2, which was expressed in two patients (2.0%). Two kinds of T-Ag were simultaneusly expressed in three patients (CD2/CD5, CD2/CD7, and CD5/CD7, each expressed in one patient). Concerning the expression pattern of T-Ag, there were no significant differences between lymph nodes and extranodal organs in the three patients with T-Ag-positive B-NHL (T-Ag(+) B-NHL) who were analysed. When comparing the clinical features between T-Ag(+) B-NHL and T-Ag-negative B-NHL (T-Ag(-) B-NHL), extranodal involvement and higher International Prognostic Index (H and H.I.) were significantly frequent in the former subgroup (P = 0.0119 and P = 0. 0302 respectively). |
| Databáze: | OpenAIRE |
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