| Autor: |
A. de Gramont, B. Lagadec, Ch. Varette, Marcel Krulik, S. Delfau, J.P. Loiseau, Jean Cady, M. Bennamoun, C. Louvet, J.E. Maisani, J. Seroka, B. Demuynck, Jean-Didier Grangé, K. Beerblock |
| Rok vydání: |
1992 |
| Předmět: |
|
| Zdroj: |
La Revue de Médecine Interne. 13:S323 |
| ISSN: |
0248-8663 |
| DOI: |
10.1016/s0248-8663(05)80910-5 |
| Popis: |
Hydroxyurea inhibits lowers the dUMP pool while increase of dUMP is a mechanism of resistance to 5FU. 71 metastatic colorectal cancer patients were treated with hydroxyure a, folinic neid and 5FU. Hydroxyurea can sometimes restore 5FU antitumoral activity without significant toxicity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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