ChemInform Abstract: Synthesis and in vitro Evaluation of a Series of Diketopiperazine Inhibitors of Plasminogen Activator Inhibitor-1

Autor:	Sukhjit Sohal, Teresa Brooks, Peter Charlton, Richard Faint, Michael Bryan Roe, Adrian Folkes, Golec Julian M C
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Biochemistry Chemistry Plasminogen activator inhibitor-1 General Medicine In vitro
Zdroj:	ChemInform. 33
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200201164
Popis:	We have synthesized and evaluated a series of diketopiperazine-based inhibitors of PAI-1. These studies resulted in the identification of 34 which inhibited PAI-1 in vitro with an IC 50 =0.2 μM. The synthesis and SAR of these compounds are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a064912d9c8947039a5fb87defc8af0b https://doi.org/10.1002/chin.200201164 Zobrazit plný text záznamu Plný text