Effect of ageing on hypoxic exercise cardiorespiratory, muscle and cerebral oxygenation responses in healthy humans

Autor: Pierre Bouzat, Paul Robach, Stéphane Doutreleau, A. Favre-Juvin, Lara Puthon, Samuel Verges
Rok vydání: 2017
Předmět:
Zdroj: Experimental Physiology. 102:436-447
ISSN: 0958-0670
DOI: 10.1113/ep085949
Popis: This study assessed the effects of aging on cardiorespiratory and tissue oxygenation responses to hypoxia both at rest and during incremental maximal exercise. Sixteen young (20 - 30 years) and 15older (60 - 70 years) healthy subjects performed two maximal incremental cycling tests in normoxia and hypoxia (inspiratory oxygen fraction: 12%). Cardiorespiratory responses, prefrontal cortex and quadriceps tissue oxygenation (near infrared spectroscopy) were measured during exercise as well as during hypercapnia at rest. The hypoxic ventilatory response was similar in young compared to older individuals at rest and during moderate intensity exercise (50% maximal power output: young 0.9 ± 0.2 versus older 1.1 ± 0.8 l min−1⋅%−1; P > 0.05) but larger in young subjects during high intensity exercise (maximal power output: 2.2 ± 0.8 versus 1.8 ± 1.1 l⋅min−1⋅%−1; P 0.05) and the hypercapnic responses did not differ between groups. Older healthy and active individuals below the age of 70 have cardiorespiratory and tissue oxygenation responses to hypoxia similar to young individuals both at rest and during moderate-intensity exercise. Despite lower hypoxic ventilatory response at maximal exercise, older individuals have similar oxygen desaturation and maximal power output reduction compared to young subjects. This article is protected by copyright. All rights reserved
Databáze: OpenAIRE
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