| Popis: |
The challenge to develop enantioselective analytical methods to quantify residues of chiral drugs (CDs) in environmental matrices is an actual and imperative issue. It is well known that enantiomers may differ in their biological activities; nevertheless, most environmental analytical methods still ignore the stereochemistry and the discrimination of the enantiomers. The knowledge about their occurrence and ecological impact in biota is crucial for an accurate risk assessment. This critical review highlights the importance of analyzing CDs in environmental matrices for various applications, emphasizing methodological trends. Chromatographic methodologies are the most used and include liquid (LC), gas (GC), supercritical fluid (SFC) and capillary electrophoresis. LC is still the most widely used though trends for greener approaches and the development of GC and SFC methods are also future directions. Some of the most recent applications, namely for environmental monitoring of surface and wastewater, biodegradation studies and forensic analysis, are presented and critically discussed. |
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