Synthesis of New bis 1-Substituted 1H-Tetrazoles via Efficient Heterocyclizations from Symmetric Dianilines, Methyl Orthoester, and Sodium Azide

Autor: Yizrell Medina-Martínez, Eduardo González-Zamora, Roberto E. Blanco-Carapia, Mónica A. Rincón-Guevara, Alejandro Islas-Jácome, Perla Islas-Jácome, Julio C. Flores-Reyes, Ilich A. Ibarra, Leticia Lomas-Romero, Alfredo López-Olvera
Rok vydání: 2019
Předmět:
Zdroj: The 23rd International Electronic Conference on Synthetic Organic Chemistry.
DOI: 10.3390/ecsoc-23-06521
Popis: The synthesis and characterization of three new bis 1-substituted 1H-tetrazoles are described. Two products were synthesized in a single step via a direct heterocyclization of primary amines, methyl orthoester (trymethyl orthoformate), and sodium azide in 30% and 91% yields, respectively. Besides, another one was prepared via a three-step synthetic strategy: SNAr (32%), nitro-group reduction (66%), and primary amine heterocyclization (83%), yielding 18%, overall. The aim behind the synthesis of new tetrazole-containing products is to construct novel MOF-like structures to evaluate their gas capture properties (CO2, CO, and SO2) under relative humidity conditions.
Databáze: OpenAIRE