A New Monoterpenoid Glucoindole Alkaloid FromDipsacus asper

Autor:	Ken Tanaka, Feng Li, Yuto Nishidono, Shiro Watanabe, Yasuhiro Tezuka
Rok vydání:	2020
Předmět:	Pharmacology Large class 010405 organic chemistry Alkaloid Dipsacus asper Plant Science General Medicine Biology 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine Drug Discovery Botany
Zdroj:	Natural Product Communications. 15:1934578X2091729
ISSN:	1555-9475 1934-578X
DOI:	10.1177/1934578x20917292
Popis:	The monoterpenoid glucoindole alkaloids comprise a large class of structurally complex natural products that have attracted widespread attention owing to their biological activities and structural diversity. In the present study, we investigated the constituents of a methanol extract of Dipsacus asper roots and obtained a new monoterpenoid glucoindole alkaloid, (3 R,5 S)-5-carboxyvincosidic acid 22-loganin ester (1), together with the known alkaloid (3 S,5 S)-5-carboxystrictosidic acid 22-loganin ester (dipsaperine) (2). We herein report our structural elucidation of 1 by spectroscopic analysis and its anti-inflammatory activity as revealed by its inhibition of nitric oxide production in lipopolysaccharide-activated RAW264.7 cells.
Databáze:	OpenAIRE
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