Interaction of Epothilone B (Patupilone) with Microtubules as Detected by Two-Dimensional Solid-State NMR Spectroscopy

Autor:	Frank Petersen, Ashutosh Kumar, Siva Jeganathan, Marc Baldus, Eva-Maria Mandelkow, Henrike Heise, Esther K. Schmitt, Teresa Carlomagno, Marcel J. J. Blommers, Christian Griesinger, Philipp Krastel
Rok vydání:	2010
Předmět:	Epothilones Crystallography Epothilone B Solid-state nuclear magnetic resonance Polymerization Microtubule Chemistry Patupilone General Medicine Nuclear magnetic resonance spectroscopy Spectroscopy
Zdroj:	Angewandte Chemie. 122:7666-7669
ISSN:	0044-8249
Popis:	Solid evidence: Induction of the polymerization of β-tubulin dimers into microtubules by epothilones, such as patupilone, by an as yet unknown mechanism leads to the apoptosis of cancer cells. Solid-state NMR spectroscopy of patupilone bound to microtubules has now enabled the identification of atomic positions of the drug that undergo clear chemical-shift changes upon binding (see correlation spectra of free (black) and complexed patupilone (red)).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a046c35ef85e8be1d3926ce80f8c3600 https://doi.org/10.1002/ange.201001946 Zobrazit plný text záznamu Plný text