Concomitant Presentation of Hemophagocytic Lymphohistiocytosis and Posttransplant Lymphoproliferative Disease-Like Lymphoma in a Mildly Immunosuppressed Leukemia Patient: An Unusual Association
| Autor: | Robert R. Wittler, David Rosen, Mohamad G. Sinno |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Vincristine
Hemophagocytic lymphohistiocytosis business.industry Hematology medicine.disease medicine.disease_cause Epstein–Barr virus Lymphoma 03 medical and health sciences Leukemia 0302 clinical medicine Oncology hemic and lymphatic diseases 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Immunology medicine Rituximab business Epstein–Barr virus infection Immunodeficiency 030215 immunology medicine.drug |
| Zdroj: | Pediatric Blood & Cancer. 63:1474-1476 |
| ISSN: | 1545-5009 |
| DOI: | 10.1002/pbc.26033 |
| Popis: | We describe a 4-year-old female with pre-B-cell acute lymphoblastic leukemia on maintenance chemotherapy, who developed hemophagocytic lymphohistiocytosis (HLH) secondary to Epstein-Barr virus (EBV) infection, complicated by an aggressive lymphoproliferative disorder. Although there was no history of bone marrow transplant or underlying immunodeficiency, EBV triggered a post-transplant lymphoproliferative disease (PTLD)-like lymphoma. Multiple regimens of chemotherapy failed to induce remission and patient developed multiorgan failure. The association of HLH with EBV-related PTLD-like lymphoproliferative disorder is rare. We present this case to highlight this unusual association so that this highly fatal disease can be recognized and promptly addressed. |
| Databáze: | OpenAIRE |
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