Selective killing of gastric cancer cells by monoclonal antibody conjugated with a chain of ricin

Autor:	Fan Daiming, Tan Lisong, Chen Xitao, Gu Yiqun, Zhang Xueyong, Huang Liqun, Pan Huizhong, Li Song
Rok vydání:	1989
Předmět:	Cancer Research biology Chemistry medicine.drug_class Biological activity Monoclonal antibody Molecular biology chemistry.chemical_compound Ricin Oncology Biochemistry Monoclonal medicine biology.protein Antibody Cytotoxicity Binding selectivity Conjugate
Zdroj:	Chinese Journal of Cancer Research. 1:34-38
ISSN:	1993-0631 1000-9604
DOI:	10.1007/bf02677112
Popis:	A specific cytotoxic agent against gastric cancer was constructed by covalently coupling the ricin A chain to monoclonal artibody, MGb2, MGb2 was modified by SPDP to introduce the 3-(2-pyridylthio) propionyl radical and then treated with a reduced A chain to give a disulfide linked conjugate, that retained the original binding specificity of the antibody moiety. The conjugate obtained retained the activity of the antibody and the biological activity of the A chain well.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a03d416df4a5ee3de89ac036afaf58f5 https://doi.org/10.1007/bf02677112 Zobrazit plný text záznamu Full text from SpringerLink