Abstract P1-10-05: Evaluation of germline whole exome sequencing of early breast cancer patients with triple negative breast cancer (TNBC) included in a prospective study of neoadjuvant chemotherapy (NAC) with epirubicin and cyclophosphamide (EC) and carboplatin-paclitaxel (PC) (BSMO 2014-01)
| Autor: | Catherine Dopchie, Heidi Van den Bulck, P Glorieux, Christel Fontaine, Ahmad Awada, Lore Decoster, Jacques De Greve, Hans Wildiers, Sylvie De Brakeleer, V. Renard, Peter Vuylsteke, Erik Teugels |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
Cancer Research Chemotherapy medicine.medical_specialty Cyclophosphamide business.industry medicine.medical_treatment Cancer medicine.disease Carboplatin chemistry.chemical_compound Breast cancer chemistry Internal medicine medicine business Exome sequencing Triple-negative breast cancer Epirubicin medicine.drug |
| Zdroj: | Cancer Research. 80:P1-10 |
| ISSN: | 1538-7445 0008-5472 |
| Popis: | Background: BSMO 2014-01 is a published prospective phase 2 study evaluating the efficacy of neoadjuvant EC and PC in the treatment of TNBC patients. (1) The addition of weekly carboplatin to neoadjuvant paclitaxel and dose-dense EC lead to a pathologic complete response (pCR) of 54%, comparable to prior studies. A secondary endpoint was to correlate pCR to homologous recombination (HR) and DNA damaging repair (DDR) deficiency due to germline mutations. Methods: Sixty-three patients (pts) of which nine already identified with a BRCA 1/2 mutation were considered. Peripheral blood was collected in 52 pts after obtaining informed consent for a broad genomic DNA analysis. Whole Exome Sequencing was performed, and only rare variants (M.A.F. Citation Format: Christel Fontaine, Vincent Renard, Heidi Van den Bulck, Peter Vuylsteke, Philippe Glorieux, Catherine Dopchie, Lore Decoster, Ahmad Awada, Hans Wildiers, Sylvie De Brakeleer, Erik Teugels, Jacques De Grève. Evaluation of germline whole exome sequencing of early breast cancer patients with triple negative breast cancer (TNBC) included in a prospective study of neoadjuvant chemotherapy (NAC) with epirubicin and cyclophosphamide (EC) and carboplatin-paclitaxel (PC) (BSMO 2014-01) [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P1-10-05. |
| Databáze: | OpenAIRE |
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