Microcalorimetric investigation of influence of cancerogenic and anticancerogenic compounds on nuclear chromatin of tumor cells

Autor:	D. G. Khachidze, J. Monaselidze, Ya. Kalandadze
Rok vydání:	1996
Předmět:	chemistry.chemical_compound medicine.anatomical_structure chemistry Benzopyrene medicine Pyrene Tumor cells Spleen Linker DNA Genome Molecular biology DNA Chromatin
Zdroj:	Journal of Thermal Analysis. 46:431-440
ISSN:	1572-8943 0368-4466
DOI:	10.1007/bf02135020
Popis:	The influence of mitoxantron (M) and benz(a)pyrene (BP) on chromatin DNA in composition of spleen and liver tissues and cells of BALB/c mice were studied using a high-sensitive differential scanning microcalorimeter. It was established that BP can cause a) the specific breaks in ‘inactive’ chromatin DNA chain and unfolding of the whole domain (a loop of chromatin) which should lead to uncontrolled genome activation; b) the breaks in the DNA double-helix creating short duplexes.M at low doses, interacting with ‘naked’ linker DNA of tumor restores the chromatin structure, at high doses or at repeated injections,M causes the disturbance of chromatin structure.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a033915e481f8ff70206c9314f0563ae https://doi.org/10.1007/bf02135020 Zobrazit plný text záznamu Full text from SpringerLink