OUP accepted manuscript

Autor: Giuseppe Stefano Netti, Laura Croce, Adelaide Di Lorenzo, Maria Teresa Rocchetti, Federica Spadaccino, Giuseppe Castellano, Morena Schirone, Giuseppe Grandaliano, Antonino Teri, Giovanni Stallone, Francesca Fortunato, Rosa Prato, Loreto Gesualdo, Francesca Coperchini, Giuseppina Iannelli, Mario Rotondi, Elena Ranieri, Domenico Papantonio, Barbara Infante, Rossella Perulli
Rok vydání: 2020
Předmět:
Zdroj: Clinical Kidney Journal.
ISSN: 2048-8513
2048-8505
DOI: 10.1093/ckj/sfaa003
Popis: Background End-stage renal disease (ESRD) is associated with a broad spectrum of morphological and functional thyroid disorders. Recent studies have shown that low free triiodothyronine (fT3) levels are related to inflammatory status and endothelial activation in ESRD patients on haemodialysis (HD). Limited data exist about a possible relationship between dialysis regimen, namely long nocturnal haemodialysis (LNHD), and thyroid function parameters. The aim of this study was to evaluate the relationship between dialysis regimen and thyroid function, and consequently with the main patient outcomes. Methods To this purpose, we performed a retrospective, single-centre cohort study including 220 incident chronic HD patients treated during an 8-year period (from January 2010 to December 2017). The main clinical and haematochemical parameters, including thyroid function, were evaluated and related to the main patient outcomes. Results Patients with low fT3 levels ( 3.05 ng/mL) (P 3.05 ng/mL was significantly higher in LNHD patients than in patients treated with diurnal dialysis. Conclusions Our data suggest that the application of alternative dialysis regimens, also reducing the frequency of low T3, could ameliorate outcomes and therefore reduce the incidence of cardiovascular events in HD patients.
Databáze: OpenAIRE
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