Comparative Analysis of Connective Tissue Responses to Implantation of Biodegradable Material and Polypropylene in Experimental Animals
| Autor: | O. I. Bondarev, V. G. Mozes, M. A. Bakarev, I. A. Eisenakh, G. A. Lapii |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Polypropylene Connective tissue Dense regular connective tissue General Medicine engineering.material Biodegradable polymer General Biochemistry Genetics and Molecular Biology Electrospinning 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure chemistry Polycaprolactone engineering Dense irregular connective tissue medicine Biopolymer 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 170:505-510 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | We compared qualitative characteristics of the connective tissue at the site of implantation of polypropylene or a biodegradable polymer synthesized by electrospinning and consisting of 65% polycaprolactone and 35% polytrimethylene carbonate. Synthetic materials were implanted into the interfascial space of the muscles on the back of Wistar rats. The parameters of cellular and non-cellular structures of the forming connective tissue were studied in 1, 2, 3, 6, 9, and 12 months after implantation. It was found that the number of fibrocytes and fibroblasts around biopolymer and polypropylene increased during the period from 1 to 9 months, with a significant lag in case of biopolymer implantation; by 12 months, the number of fibrocytic cells did not significantly differ. The fibroplastic and angioplastic processes developed in the thickness of both materials, but with a one-month lag in case of biopolymer implantation due to degradation properties and nonporous structure of this polymer. Collagen fibers were actively synthesized around both materials, but in case of polypropylene, this process was more pronounced. In 6 months after implantation of polypropylene, dense regular connective tissue was formed; in 12 months after implantation of the biopolymer, the formation of dense irregular connective tissue was observed at the site of implantation. The biopolymer can be used to strengthen the core muscles. |
| Databáze: | OpenAIRE |
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