Intracellular Invasion by Streptococcus pyogenes : Invasins, Host Receptors, and Relevance to Human Disease
| Autor: | Beinan Wang, P. Patrick Cleary |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Microbiology (medical)
Physiology Virulence Drug resistance Biology medicine.disease_cause Microbiology Sepsis Pathogenesis 03 medical and health sciences Genetics medicine 030304 developmental biology 0303 health sciences General Immunology and Microbiology Ecology Tight junction 030306 microbiology Cell Biology medicine.disease Pharyngitis Infectious Diseases Streptococcus pyogenes Immunology medicine.symptom Intracellular |
| Zdroj: | Gram-Positive Pathogens |
| ISSN: | 2165-0497 |
| Popis: | The human oral-nasal mucosa is the primary reservoir for Streptococcus pyogenes infections. Although the most common infection of consequence in temperate climates is pharyngitis, the past 25 years have witnessed a dramatic increase in invasive disease in many regions of the world. Historically, S. pyogenes has been associated with sepsis and fulminate systemic infections, but the mechanism by which these streptococci traverse mucosal or epidermal barriers is not understood. The discovery that S. pyogenes can be internalized by mammalian epithelial cells at high frequencies ( 1 – 3 ) and/or open tight junctions to pass between cells ( 4 ) provides potential explanations for changes in epidemiology and the ability of this species to breach such barriers. In this article, the invasins and pathways that S. pyogenes uses to reach the intracellular state are reviewed, and the relationship between intracellular invasion and human disease is discussed. |
| Databáze: | OpenAIRE |
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