| Popis: |
Department of Chemistry, University of Jodhpur, Jodhpur-342 001 Manuscript received 19 October 1989, revised 12 October 1990, accepted 6 December 1990 A large number of quaternary ammonium halides have been reported to exhibit various biological activities. A previous study on the synthesis2 of some quaternary β-ketoalkyl ammonium halides as potential antimicrobial agents gave us the necessary impetus to synthesise some new quaternary ammonium halides and evaluate their antifungal activity. We report here the synthesis of a series of N-(3-methyl-2-oxobutyl) quaternary ammonium bromides and iodides (in good yields) by the reaction of 3-methylbut-2-one and halogens (bromine/ iodine) with various heterocyclic tertiary bases in isopropanol. Since the preparation of these compounds by known method3'4 could not be achieved, we have shown that N-(3-methyl-2-oxobutyl) quaternary ammonium halides could be conveniently synthesised by changing the reaction medium from methanol to isopropanol. These compounds gave the characteristic colour reactions of the enolbetaines (ylids)4. The compounds (Table 1) were characterised on the basis of their elemental analysis and spectral data. |
