Interconversible cis and trans rotational isomers of 1,8-di(1-naphthyl)naphthalene

Autor:	Hiroshi Mizutani, Shigeru Ozasa, Eiichi Ibuki, Yasuhiro Fujioka
Rok vydání:	1981
Předmět:	chemistry.chemical_classification Iodide Solid-state General Chemistry General Medicine Photochemistry Medicinal chemistry Proton magnetic resonance chemistry.chemical_compound chemistry Drug Discovery Melting point Conformational isomerism Cis–trans isomerism Naphthalene
Zdroj:	Chemical and Pharmaceutical Bulletin. 29:2103-2106
ISSN:	1347-5223 0009-2363
DOI:	10.1248/cpb.29.2103
Popis:	New stable cis and trans rotational isomers of 1, 8-di (1-naphthyl) naphthalene were prepared by the Kharash-type Grignard cross-coupling of 1-naphthylmagnesium iodide and 1, 8-diiodonaphthalene in the presence of N, N'-bis (1-methyl-3-oxobutylidene) ethylene-diaminatonickel (II). Thermoanalytical and proton magnetic resonance spectral studies indicated that both rotamers are stable in the solid state as well as in a solution, but are interconversible at temperatures above their melting points. A convenient method, obtaining pure trans rotamer from the equilibrium mixture of both rotamers, is also presented.
Databáze:	OpenAIRE
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