Skeletal muscle pH dynamics during arousal from hibernation measured by31P NMR spectroscopy
| Autor: | L. C. H. Wang, C. C. Hanstock, P. S. Allen, André Malan, M. D. McArthur |
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| Rok vydání: | 1990 |
| Předmět: |
Hibernation
Muscle metabolism medicine.medical_specialty Physiology Skeletal muscle Nuclear magnetic resonance spectroscopy Intracellular acidification Biology biology.organism_classification Biochemistry Neck muscles Arousal Endocrinology medicine.anatomical_structure Internal medicine medicine Animal Science and Zoology Ground squirrel Ecology Evolution Behavior and Systematics |
| Zdroj: | Journal of Comparative Physiology B. 160:339-347 |
| ISSN: | 1432-136X 0174-1578 |
| DOI: | 10.1007/bf01075664 |
| Popis: | The time-course of changes in skeletal muscle pH during arousal from hibernation in the Columbian ground squirrel was studied using31P NMR spectroscopy. In hibernation (Tre 7–9°C), shoulder/neck muscle pH was 7.45±0.03 and αIm was 0.60. In euthermia (Tre 37°C), muscle pH was 7.24±0.05 and αIm was 0.75. Thus the overall pH-temperature coefficient was-0.009 pH units/°C, indicating acidification of the muscle in hibernation. During the transition from hibernation to euthermia, however, the muscle shows a nonlinear pattern of pH change. In early arousal (Tsh 20–25°C,Tre>15°C) muscle pH decreases gradually toward the euthermic value and muscle αIm increases only slightly from 0.72 to 0.75. These results support the hypothesis that intracellular acidification of the muscle, present during hibernation, is reversed in early arousal. This may facilitate an increase in muscle metabolism and the contribution of maximal shivering thermogenesis to rewarming of the animal. |
| Databáze: | OpenAIRE |
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