Expression of embryonic zeta-globin and epsilon-globin chains in a 10- year-old girl with congenital anemia
| Autor: | David H.K. Chui, Wozhan Tang, Barry Eng, John S. Waye, Shi-Ping Cai, Man-Chiu Poon, N. Illum |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Congenital Anemia
medicine.medical_specialty Anemia business.industry media_common.quotation_subject Immunology Normal level Cell Biology Hematology medicine.disease Biochemistry Embryonic stem cell Endocrinology medicine.anatomical_structure Reticulocyte hemic and lymphatic diseases Internal medicine medicine Erythropoiesis Girl Globin business media_common |
| Zdroj: | Blood. 81:1636-1640 |
| ISSN: | 1528-0020 0006-4971 |
| Popis: | A 10-year-old Danish girl with congenital anemia is described. At birth, she had severe anemia and erythroblastosis and was transfused a number of times during the first year. The need for transfusions has since declined steadily. Her reticulocyte counts varied between 2% and 15%, and her bone marrow aspirate showed some dyserythropoietic features. Her hemoglobin F level was consistently elevated, up to as much as 41%. Her erythrocytes had a normal level of I antigen but an undetectable level of i antigen. Moreover, embryonic zeta-globin and epsilon-globin chains were present in some of her circulating erythrocytes. These findings may represent the manifestations of a new variant of congenital anemia. |
| Databáze: | OpenAIRE |
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