Inhibition of the Toxic Effects ofLachesis muta,Crotalus durissus cumanensisandMicrurus mipartitusSnake Venoms by Plant Extracts
| Autor: | Vitelbina Núñez, Juan C Quintana, Silvia L. Jiménez, Rafael Otero, A. Díaz, R.G. Osorio, R. Fonnegra, Jacqueline Barona |
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| Rok vydání: | 2004 |
| Předmět: |
Pharmacology
biology Traditional medicine Intraperitoneal route Pharmaceutical Science Crotalus Venom General Medicine biology.organism_classification Lachesis muta Renealmia alpinia Micrurus mipartitus Ethanol extracts Complementary and alternative medicine Drug Discovery Botany Molecular Medicine Brownea |
| Zdroj: | Pharmaceutical Biology. 42:49-54 |
| ISSN: | 1744-5116 1388-0209 |
| DOI: | 10.1080/13880200490505483 |
| Popis: | The ethanol extracts of eight plants utilized against snakebites by traditional healers in Colombia (Pleopeltis percussa, Trichomanes elegans, Brownea rosademonte, Tabebuia rosea, Heliconia curtispatha, Bixa orellana, Renealmia alpinia and Citrus limon) were examined for their possible inhibitory ability against the venoms of Lachesis muta, Crotalus durissus cumanensis, and Micrurus mipartitus. Extracts were preincubated with 1.5 LD50 of each venom, and injected by the intraperitoneal route, in mice. Under these conditions, the lethal effect of L. muta venom was neutralized by all of the extracts, whereas C. d. cumanensis and M. mipartitus venoms were inhibited by six extracts, exceptions being P. percussa and C. limon. In addition, the myotoxic activity of C. d. cumanensis venom was neutralized by the extracts of H. curtispatha, B. rosademonte, P. percussa, and T. elegans. The neutralizing ability of the plant extracts was also evaluated by independent administration experiments. Extracts were injected b... |
| Databáze: | OpenAIRE |
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