Allelic variation at thefrizzled locus ofDrosophila

Autor:	Paul N. Adler, Charles R. Vinson, Jeannette Charlton
Rok vydání:	1987
Předmět:	Genetics Frizzled Normal tissue Locus (genetics) Cell Biology Biology Bristle biology.organism_classification Phenotype Drosophilidae Tissue specific Allele Developmental Biology
Zdroj:	Developmental Genetics. 8:99-119
ISSN:	1520-6408 0192-253X
DOI:	10.1002/dvg.1020080206
Popis:	The epidermis of Drosophila has a tissue polarity that is manifested by a parallel array of polarized structures (primarily hairs and bristles). The production of normal tissue polarity requires the function of the frizzled (fz) locus. We have isolated a large number of alleles at this locus and have phenotypically characterized more than 25 of them. We have found extensive allelic variation that a previous study failed to detect. Most of the alleles fall into a hypomorphic to amorphic series. Two alleles, however, have unusual properties. These alleles, which in general are moderately strong alleles, fail to produce a rough eye phenotype that is characteristic of all the other moderate or strong fz alleles. Thus, these two alleles are tissue specific in effect. Furthermore, these two alleles also have a neomorphic or antimorphic effect on hair polarity in one region of the wing.
Databáze:	OpenAIRE
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