The effects of vitamin D metabolites and their analogues on the secretion of parathyroid hormone
| Autor: | E. B. Mawer, J. L. H. O’Riordan, C. M. Taylor, Munro Peacock, S. Tomilnson, R. F. L. Bates, A. W. Norman, Hector F. DeLuca, A. D. Care, D. W. Pickard |
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| Rok vydání: | 1975 |
| Předmět: |
Vitamin
medicine.medical_specialty Endocrinology Diabetes and Metabolism Metabolite Parathyroid hormone Biological activity General Medicine Small intestine chemistry.chemical_compound Endocrinology Vitamin D+Metabolites medicine.anatomical_structure chemistry Internal medicine medicine Orthopedics and Sports Medicine Secretion Normal concentration |
| Zdroj: | Calcified Tissue Research. 21:142-146 |
| ISSN: | 1432-0827 0008-0594 |
| DOI: | 10.1007/bf02546442 |
| Popis: | 1,25-dihydroxycholecalciferol (1,25-DHCC) is the major biologically active metabolite of vitamin D3 in the small intestine and bone, whereas roles for 24,25-dihydroxycholecalciferol and 25, 26-dihydroxycholecalciferol have yet to be assigned. All three metabolites have been detected in plasma, the approximate concentration in a normal individual being 60 pg/ml for 1,25-DHCC (4), 0–4 ng/ml for 24,25-DHCC (13) and 200–1000 pg/ml for 25,26-DHCC (Mawer & Taylor, unpublished results). The principal circulating metabolite is 25-hydroxycholecalciferol (25-HCC) the normal concentration of which in healthy humans in Britain is 12 ng/ml, with a range of 4 to 33 ng/ml (12). |
| Databáze: | OpenAIRE |
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