Flexible hydrophobic filter paper-based SERS substrate using silver nanocubes for sensitive and rapid detection of adenine
| Autor: | Agaje Bedemo Beyene, Wodaje Addis Tegegne, Meng-Che Tsai, Wei-Hsiang Huang, Bing-Joe Hwang, Wei-Nien Su |
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| Rok vydání: | 2021 |
| Předmět: |
Detection limit
Materials science Filter paper business.industry 010401 analytical chemistry Nanoparticle Substrate (chemistry) 02 engineering and technology Surface-enhanced Raman spectroscopy 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Analytical Chemistry Contact angle Rhodamine 6G chemistry.chemical_compound chemistry Optoelectronics Sample collection 0210 nano-technology business Spectroscopy |
| Zdroj: | Microchemical Journal. 168:106349 |
| ISSN: | 0026-265X |
| Popis: | Flexible paper-based surface enhanced Raman spectroscopy (SERS) substrate has attracted great attention in the sensitive detection of analytes in recent years. However, due to its inherent hydrophilic surface, the nanoparticles will not be concentrated very well on the surface of the paper. This reduces the reproducibility and sensitivity of the paper-based substrate. Herein, we demonstrate flexible hydrophobic paper-based substrate using silver nanocubes loaded on polymethylhydrosiloxane modified filter paper (AgNCs@SiO2/PMHS modified filter paper) to realize high sensitivity and reproducibility. The hydrophobic filter paper was obtained by dip-soaking the filter paper into PMHS solution, resulting in increased contact angle to ~112.5°. The AgNCs@SiO2/PMHS modified paper substrate shows high analytical enhancement factor (AEF) of 6.55 × 106, which is 2.2-fold enhancement compared to AgNCs@SiO2/normal paper substrate, and a low detection limit of 0.1 nM rhodamine 6G and 0.89 nM adenine. The high SERS enhancement factor and sensitivity is attributed to the high hotspots density created in the hydrophobic surface as a result of the excellent uniformity and superior sample collection efficiency compared to the normal filter paper-based substrate. Besides, the substrate shows excellent spot-to-spot and substrate-to-substrate reproducibility, with relative standard deviation (RSD) of 6.05% and 9.22%, respectively. Moreover, the AgNCs@SiO2/PMHS modified filter paper substrate achieved good stability; the Raman signal intensity only drops by 25.88% after 3 months of exposure to air. Therefore, this flexible hydrophobic AgNCs@SiO2/PMHS modified filter paper substrate with low cost fabrication and label-free SERS detection is a promising SERS platform for analytical and biological sensing applications. |
| Databáze: | OpenAIRE |
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