Synthesis and preliminary pharmacological study of new amidinobenzisothiazoles

Autor:	Vigilio Ballabeni, Elisabetta Barocelli, Milena Chiavarini, L. Amoretti, Paola Vicini
Rok vydání:	1993
Předmět:	Pharmacology Papaverine Bicyclic molecule Stereochemistry Chemistry Organic Chemistry Analgesic Biological activity General Medicine Antispasmodic Agent Amidine chemistry.chemical_compound Drug Discovery Nucleophilic substitution medicine Organic chemistry Antipyretic medicine.drug
Zdroj:	European Journal of Medicinal Chemistry. 28:955-961
ISSN:	0223-5234
DOI:	10.1016/0223-5234(93)90051-f
Popis:	Some new N -(1,2-benzisothiazol-3-yl)amidines were synthesized and tested for antiinflammatory, antipyretic, analgesic and spasmolytic activities in comparison with indomethacin and papaverine respectively. The synthesis of the new compounds has been described. All the amidinobenzisothiazoles showed remarkable analgesic action and an interesting antiphlogistic action, while only one drug displayed a certain antipyretic activity. As regards spasmolytic activity, 3 compounds out of 6 demonstrated a papaverine-like effect.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9fd1ee6bda2bfdf389fc0055ce9b5362 https://doi.org/10.1016/0223-5234(93)90051-f Zobrazit plný text záznamu