| Autor: |
Yu. R. Buldakova, V. T. Timofeev, R. I. Stryuk, N. I. Sharova, Natalia Lakhonina, Mark Goloviznin |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
IFMBE Proceedings ISBN: 9783540928409 |
| DOI: |
10.1007/978-3-540-92841-6_401 |
| Popis: |
We found that the level of CD3+4+8+T-cells was normal in peripheral blood of RA patients. Otherwise an amount of CD3+4-8-, CD3-4+ and CD3-8+ subpopulations was increased in 10 patients and level of CD10+ cells (24%) in 2. We found also significant imbalance of CD3+4+8- and CD3+4-8+ mature T-cells in all RA patients The level of CD3+4+ 5-40-fold exceeded the level of CD3+8+. The 24-hour incubation of RA patient’s lymphocytes with human TEC culture and TEC supernatant could influence upon T-cell receptor phenotype. We found tendency to increase of CD3 after the incubation in all patients. Otherwise the dynamic of CD4 and CD8 was different. In 4 cases we saw the moderate decrease of CD4 expression and increase of CD8. But in 9 cases the imbalance of CD3+4+ and CD3+8+ subpopulations increased after cultivation due to progressive CD8 expression diminution. The above mentioned facts allowed us to suppose the heterogeneity of T-cell selection disturbances in RA |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
