Marking Disappearing Colorectal Liver Metastases After Complete Response to Neoadjuvant Chemotherapy via CT – A Pilot Study
| Autor: | Peter Kornprat, Valerie Wienerroither, Katharina Marsoner, H. Bacher, Jovan Vujic, Hans-Jörg Mischinger, Helmut Schöllnast |
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| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Anticancer Research. 39:3847-3854 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.13534 |
| Popis: | BACKGROUND/AIM The liver is a frequent site for metastases of colorectal cancer. Approximately 15% of patients have hepatic metastases at the time of diagnosis and another 50% develop them over the course of their disease. Only 10-25% of patients are candidates for liver resection. The aim of this study was to assess the benefit of preoperative computed tomography (CT)-guided wire marking of disappearing colorectal liver metastases (CRLMs) (radiological disappearance of metastases) before surgical resection. PATIENTS AND METHODS Between January 2011 and January 2014, 20 patients with potentially disappearing CRLMs were selected for CT-guided wire marking. Following treatment with neoadjuvant chemotherapy, disappearing CRLMs were marked via CT guidance. Afterwards, the marked sites were resected. RESULTS Complete histological response to neoadjuvant chemotherapy was only in 10 resected sites (18%), and 46 (82%) resected liver metastases showed metastatic tissue present. Both overall survival and the disease-free rates in patients after using our method were 55%. CONCLUSION This study demonstrated the usefulness of CT-guided wire marking to mark disappearing CRLMs in order to improve long-term effectiveness of surgical treatment. |
| Databáze: | OpenAIRE |
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