Combination of inulin and compound probiotic exert synergism in attenuating HFD-induced obesity but shows gender-difference
| Autor: | Weihao Xu, Zhiwei Li, Zeang Wu, Yongxin Chen, Mire Guli, Zhihao Li, Haixia Wang |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
030309 nutrition & dietetics Endocrinology Diabetes and Metabolism medicine.medical_treatment Inulin Blood lipids Adipokine law.invention 03 medical and health sciences chemistry.chemical_compound Probiotic law Internal medicine Internal Medicine medicine chemistry.chemical_classification 0303 health sciences Nutrition and Dietetics business.industry Prebiotic digestive oral and skin physiology nutritional and metabolic diseases food and beverages Fatty acid medicine.disease Obesity Endocrinology chemistry lipids (amino acids peptides and proteins) medicine.symptom business Weight gain hormones hormone substitutes and hormone antagonists |
| Zdroj: | Nutrition Clinique et Métabolisme. 34:319-325 |
| ISSN: | 0985-0562 |
| Popis: | Objectives Our goal was to test the anti-obesity effects of supplementing inulin and compound probiotic (CP) alone or in combination on HFD-mice model. Material and methods Fifty C57BL/6 mice were randomly divided into five groups of varying diets as follows: normal chow diet (NCD), high-fat diet(HFD), HFD + inulin, HFD + CP, HFD + inulin + CP. Each group consisted of five males and five females. All mice were sacrificed to test obesity parameters adipocytokines、blood lipid parameters and inflammatory factor after seven weeks. Results Compared to male mice HFD group, the supplement of inulin and CP alone significantly improved HFD-induced obesity by regulating weight gain blood lipid metabolism inflammatory cytokines and adipokines. However, inulin combined CP had a better anti-obesity effect. For the female mice, body weight blood lipids and glucose liver weight and Free fatty acid (FFA) were influenced to different degrees. Besides, the beneficial effects of inulin and CP treatment on HFD-induced obesity showed gender-difference. Conclusion This study demonstrated that prebiotic inulin and CP could have paly antiobesity effects on HFD male mice, respectively. The synergism of inulin combined with CP on improving HFD-induced obesity was observed in our study. Meanwhile, there were differences between male and female mice of above beneficial effects, providing a rational therapeutic method of HFD-induced obesity in the future. |
| Databáze: | OpenAIRE |
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