Practical Synthesis of (+)-Alloisoleucine

Autor:	Czeslaw Belzecki, Jerzy Trojnar, Marek Chmielewski
Rok vydání:	2000
Předmět:	Acylation chemistry.chemical_compound Recrystallization (geology) Hydroxylamine Alloisoleucine chemistry Organic Chemistry Organic chemistry Imide Saponification
Zdroj:	Synthetic Communications. 30:2245-2252
ISSN:	1532-2432 0039-7911
Popis:	Subsequent treatment of N-crotoyl-(1S,2R)-bornane-10,2-sultam with EtMgCl, recrystallization of the product and saponification, afforded R-(-)-3-methylpenthanoic acid which was used for acylation of (1R,2S)-bornane-10,2-sultam. The product was converted into N-[(2S,3R)-2-amino-3-methylpentanoyl]-(1R,2S)-bornane-10,2-sultam by hydroxyamination with 1-chloro-1-nitrosocyclohexane, followed by reduction of the hydroxylamine grouping. Saponification of the sultam imide provided (+)-alloisoleucine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9f999be265a6da660eed361a701e825e https://doi.org/10.1080/00397910008087404 Zobrazit plný text záznamu