Mechanism and biomarkers for neurodegenerative diseases: A systematic review

Autor:	Harshita Arun Pardhe, Narayan Sah Sonar, Hemalatha S, N. C Nagalakshmi, Nandini S
Rok vydání:	2020
Předmět:	medicine.medical_specialty biology business.industry Mechanism (biology) Multiple sclerosis Disease medicine.disease Bioinformatics medicine.disease_cause medicine biology.protein Dementia Neurosurgery business Neuropharmacology Oxidative stress Neurotrophin
Zdroj:	IP Indian Journal of Neurosciences. 6:14-19
ISSN:	2581-916X 2581-8236
DOI:	10.18231/j.ijn.2020.003
Popis:	Neurodegenerative disease such as Parkinson’s disease (PD), Alzheimer’s disease (AD), Multiple sclerosis (MS), Huntington’s disease (HD) are characterized by progressive loss of cognitive function, dementia and problems with movement. Neuronal loss is associated with extra and intercellular accumulation of misfolding proteins, oxidative stress, free radical formation, mitochondrial dysfunction, disruption of neuronal golgi apparatus, impaired bioenergetics, dysfunction of neurotrophins. Biomarkers that might aid in the diagnosis of these devastating and globally important disease are urgently sought and required. Therefore, range of biomarkers are explained for neurodegenerative disease. Keywords: Neurodegeneration, Alzheimer’s disease, Parkinson’s disease, Biomarkers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9f9800683ae7485f05202a7439f23d88 https://doi.org/10.18231/j.ijn.2020.003 Zobrazit plný text záznamu