Potential associations between perihepatic lymph node enlargement and liver fibrosis, hepatocellular injury or hepatocarcinogenesis in chronic hepatitis B virus infection
| Autor: | Masaya Sato, Mamiko Sato, Tomokazu Matsuura, Hitoshi Ikeda, Hiroaki Gotoh, Shu Hagiwara, Tomomi Iwai, Yoko Soroida, Hiroshi Yotsuyanagi, Soichi Kojima, Hiromi Hikita, Kazuhiko Koike, Yutaka Yatomi, Atsushi Suzuki |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Pathology Hepatology business.industry Hepatitis B medicine.disease Chronic liver disease Gastroenterology digestive system diseases Virus Infectious Diseases medicine.anatomical_structure Immune system Interferon Fibrosis Hepatocellular carcinoma Internal medicine Medicine business Lymph node medicine.drug |
| Zdroj: | Hepatology Research. 45:397-404 |
| ISSN: | 1386-6346 |
| DOI: | 10.1111/hepr.12361 |
| Popis: | Aim Although perihepatic lymph node enlargement (PLNE) is frequently observed in chronic liver disease, little is known about PLNE in chronic hepatitis B virus (HBV) infection. We aimed to evaluate this issue. Methods We originally enrolled a consecutive 502 patients with chronic HBV infection. Among them, 288 patients without history of interferon-based or nucleoside analog treatment and hepatocellular carcinoma (HCC) were primarily analyzed. Results PLNE was detected in 27 of 288 (9.4%) patients, which was fewer than that in chronic hepatitis C patients but more than that in subjects undertaking a general health examination as previously reported. The presence of PLNE was significantly associated with a higher probability of having an aspartate aminotransferase (AST) platelet ratio index of more than 1.5 (11.1% vs 1.5%, P = 0.01), a higher AST level (38.0 vs 26.8 U/L, P = 0.001), a higher alanine aminotransferase level (50.1 vs 28.0 U/L, P |
| Databáze: | OpenAIRE |
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