Genetically Engineered Animal Models: Physiological Studies with Gastrin in Transgenic Mice
| Autor: | K. Hormi, G. J. Dockray, Timothy C. Wang, G. W. Bate, R Dimaline, András Varró |
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| Rok vydání: | 2002 |
| Předmět: |
Genetically modified mouse
digestive oral and skin physiology Regulator Biology digestive system Cell biology chemistry.chemical_compound medicine.anatomical_structure chemistry medicine Secretion Genetically modified mammal Receptor hormones hormone substitutes and hormone antagonists Histamine Gastrin Parietal cell |
| Zdroj: | Mechanisms and Consequences of Proton Transport ISBN: 9781461353300 |
| DOI: | 10.1007/978-1-4615-0971-4_20 |
| Popis: | The role of gastrin as a regulator of acid secretion has been appreciated for almost a century.(13) For many years it has been clear that while gastrin may act directly on parietal cells, it also acts on enterochromaffin-like (ECL) cells to control histamine release which in turn stimulates acid secretion.(33) It is presently thought that this effect is of primary physiological importance in the control of post-prandial acid secretion. In addition, gastrin has long been considered to be a regulator of gastric mucosal proliferation, although it remains controversial as to whether or not proliferating cells in the stomach normally express the gastrin-CCKB receptor, which is the main receptor mediating the effect of COOH-terminally amidated gastrins. |
| Databáze: | OpenAIRE |
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