PET visualization of microglia in multiple sclerosis patients using [11 C]PK11195
| Autor: | Jan Versijpt, Guido Slegers, K. Van Laere, Eric Achten, J. De Reuck, Jan Debruyne, Karel Strijckmans, F. De Vos, Rudi Dierckx, J Korf, J Keppens |
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| Rok vydání: | 2003 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test Microglia business.industry Multiple sclerosis Magnetic resonance imaging Human brain medicine.disease Brain mapping White matter medicine.anatomical_structure Neurology Positron emission tomography medicine Radioligand Neurology (clinical) business |
| Zdroj: | European Journal of Neurology. 10:257-264 |
| ISSN: | 1351-5101 |
| Popis: | Activated microglia are involved in the immune response of multiple sclerosis (MS). The peripheral benzodiazepine receptor (PBR) is expressed on microglia and up-regulated after neuronal injury. [11C]PK11195 is a positron emission tomography (PET) radioligand for the PBR. The objective of the present study was to investigate [11C]PK11195 imaging in MS patients and its additional value over magnetic resonance imaging (MRI) concerning the immuno-pathophysiological process. Seven healthy and 22 MS subjects were included. Semiquantitative [11C]PK11195 uptake values were assessed with normalization on cortical grey matter. Uptake in Gadolinium-lesions was significantly increased compared with normal white matter. Uptake in T2-lesions was generally decreased, suggesting a PBR down-regulation. However, uptake values increased whenever a clinical or MR-relapse was present, suggestive for a dynamic process with a transient PBR up-regulation. During disease progression, an increase of normal-appearing white matter (NAWM) uptake was found, propagating NAWM as the possible real burden of disease. In conclusion, [11C]PK11195 and PET are able to demonstrate inflammatory processes with microglial involvement in MS. |
| Databáze: | OpenAIRE |
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