Prenatal and Neonatal Diazepam Administration Synchronizes Testicular Malate Dehydrogenase Circadian Rhythms in Young Rats

Autor:	S. L. Bellavia, Agata R. Carpentieri, N. T. Vermouth
Rok vydání:	2001
Předmět:	endocrine system Fetus medicine.medical_specialty Physiology GABAA receptor Circadian clock Hamster Biology Malate dehydrogenase Melatonin Endocrinology Physiology (medical) Internal medicine medicine Circadian rhythm Diazepam Ecology Evolution Behavior and Systematics medicine.drug
Zdroj:	Biological Rhythm Research. 32:207-219
ISSN:	1744-4179 0929-1016
DOI:	10.1076/brhm.32.2.207.1355
Popis:	Rat or hamster pups exposed to constant light or darkness since birth exhibit many circadian rhythms synchronized with those of the mother. During early development, a number of cues derived from the maternal circadian system synchronize the fetal and neonatal circadian clock. Maternal pineal sympathetic denervation during early pregnancy disrupts maternal synchronization of parotid α-amylase and testicular malate dehydrogenase circadian rhythms in rat pups. Maternal pineal sympathetic denervation was used to study potential agents able to synchronize the fetal or neonatal circadian clock. Melatonin injection to denervated pregnant mothers prevents the pineal sympathetic denervation effect on those circadian rhythms. We now studied the synchronizing effect of a benzodiazepine compound, diazepam. This GABAA agonist synchronized testicular malate dehydrogenase (MDH) activity of pups when it was injected to sympathetic denervated pregnant dams (a daily dose at 07:00 or 19:00 h from the 14 th to the 20 th day...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9f76d3db47771234d4b4ae4c1ab9593b https://doi.org/10.1076/brhm.32.2.207.1355 Zobrazit plný text záznamu