| Autor: |
S. Golzio dos Santos, M. de F. F. Melo Diniz, Mateus Feitosa Alves, Luciana Scotti, Marcus Scotti |
| Rok vydání: |
2017 |
| Předmět: |
|
| DOI: |
10.1016/b978-0-08-101129-4.00004-7 |
| Popis: |
Pharmacological receptors are important because they produce an interaction with drugs leading to a biological response. The β1- and β2-adrenergic receptors are found in cardiac muscle and bronchial tissue. The family Menispermaceae is composed of over 70 genera with a wide global distribution, many of them having different pharmacological activities. Several secondary metabolites, particularly alkaloids, have been isolated from this family. The aim of this study was to evaluate a number of alkaloids and their affinity to β1- and β2-adrenergic receptors. Therefore, a combination of ligand- and structure-based virtual screening methods was applied to the study of a small data set formed by 786 secondary metabolites of the Menispermaceae family that were extracted from an in-house database. The multitarget selectivity of the alkaloid dauricine (482) was observed through the inhibition of β1-adrenergic receptors and activation of β2-adrenergic receptors. These compounds can be used as starting points for studies of proposed structures for cardioprotective and/or antiasthmatic activity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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