| Autor: |
Cheng Yu Lee, George J. Watase, Zsolt Venkei, Scott D. Pletcher, Bitarka Bisai, Yukiko M. Yamashita, Lindy Jensen |
| Rok vydání: |
2021 |
| Předmět: |
|
| DOI: |
10.1101/2021.04.07.438888 |
| Popis: |
Tissue-specific stem cells maintain tissue homeostasis by providing a continuous supply of differentiated cells throughout the life of organisms. Differentiated/differentiating cells can revert back to a stem cell identity via dedifferentiation to help maintain the stem cell pool beyond the lifetime of individual stem cells. Although dedifferentiation is important to maintain the stem cell population, it is speculated to underlie tumorigenesis. Therefore, this process must be tightly controlled. Here we show that a translational regulatorme31Bplays a critical role in preventing excess dedifferentiation in theDrosophilamale germline: in the absence ofme31B, spermatogonia (SGs) dedifferentiate into germline stem cells (GSCs) at a dramatically elevated frequency. Our results show that the excess dedifferentiation is likely due to misregulation ofnos,a key regulator of germ cell identity and GSC maintenance. Taken together, our data reveal negative regulation of dedifferentiation to balance stem cell maintenance with differentiation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
