Cystein-containing peptides induce migration of monocytes

Autor:	Pal'keeva Me, N. Yu. Ruleva, E A Pylaeva, A. S. Molokoedov, Maria Sidorova, Zh. D. Bespalova, A. A. Az’muko, T. L. Krasnikova, Tatiana I. Arefieva
Rok vydání:	2015
Předmět:	chemistry.chemical_classification Chemokine Leukocyte migration biology Stereochemistry Monocyte Organic Chemistry Motility Peptide Chemotaxis Biochemistry In vitro chemistry.chemical_compound medicine.anatomical_structure chemistry Peptide synthesis medicine biology.protein
Zdroj:	Russian Journal of Bioorganic Chemistry. 41:10-18
ISSN:	1608-330X 1068-1620
DOI:	10.1134/s1068162015010124
Popis:	The automated Fmoc solid-phase technique was used to synthesize Cys-containing linear peptide fragments of monocyte chemoattractant protein-1, chemokine domain of fractalkine, and their analogues, with the Cys residue being either modified or replaced with Ser. Chimeric symmetric and asymmetric disulfides were also prepared from the linear precursors. A SAR study of a set of the newly synthesized peptides showed that the capacity to stimulate migration of monocytes and influence cell motility in vitro critically depends, in general, on the presence of free Cys thiol group in the molecule. Notably, all analogues, including chimeric disulfides, containing no SH groups demonstrated the lack of chemokinetic properties.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9f71bd5e58929984731117538a89b662 https://doi.org/10.1134/s1068162015010124 Zobrazit plný text záznamu Full text from SpringerLink