Inhibitory Effect of Curcuma longa L. Extracts on 5-Alpha Reductase II Activity
| Autor: | Kwon Tack Hwang, Yung-Jae Kim, Ho-Geun Yoon, Woojin Jun, Jeong Yoon Lee, Min Seok Cha, Yoo-Hyun Lee, Jong Yeon Kim |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Nutrition and Dietetics biology Chemistry Pharmacology Reductase Hyperplasia medicine.disease biology.organism_classification Enzyme Endocrinology Dihydrotestosterone Internal medicine LNCaP medicine Curcuma Inhibitory effect Testosterone Food Science medicine.drug |
| Zdroj: | Journal of the Korean Society of Food Science and Nutrition. 43:318-322 |
| ISSN: | 1226-3311 |
| DOI: | 10.3746/jkfn.2014.43.2.318 |
| Popis: | 5-Alpha reductase Ⅱ, which converts testosterone (T) to dihydrotestosterone (DHT), is a crucial enzyme Ⅱ in benign prostatic hyperplasia. Inhibitory effects of Curcuma longa L. (CL) extracts on 5-alpha reductase Ⅱ activity were investigated in rat prostate tissue homogenates as well as LNCaP cells expressing human 5-alpha reductase Ⅱ. Hot water extract (CL-HW) of Curcuma longa L. significantly inhibited 5-alpha reductase activity by over 80% at a concentration of 100 μg/mL, whereas 20% ethanol extracts (CL-E20) of Curcuma longa L. exhibited significant inhibitory activity from 50 μg/mL. These results indicated that Curcuma longa L is a potent 5-alpha reductase Ⅱ inhibitor for benign prostatic hyperplasia treatment. |
| Databáze: | OpenAIRE |
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