Reaction of derivatives of ?-alkylthio-?-chloroisovaleric acid with ammonia

Autor:	M. G. Lin'kova, L. P. Rasteikene, V. A. Zabelaite-Mishkinene, I. L. Knunyants, E. A. Stumbrevichyute
Rok vydání:	1978
Předmět:	Ammonia chemistry.chemical_compound chemistry Nitromethane Inorganic chemistry Chlorine Substituent chemistry.chemical_element General Chemistry Methanol Medicinal chemistry Ion
Zdroj:	Bulletin of the Academy of Sciences of the USSR Division of Chemical Science. 27:952-956
ISSN:	1573-9171 0568-5230
DOI:	10.1007/bf00928999
Popis:	1. The replacement of chlorine by ammonia in anilides of α-alkylthio-β-chloroisovaleric acid in nitromethane, methanol, and water takes place with the formation of an episulfonium ion and results in the formation of anilides of S-alkyl-β,β-dimethylcysteine and isodimethylcysteine. 2. Methyl α-alkylthio-β-chloroisovalerates react with liquid NH3 and its solutions methanol and nitromethane according to a mechanism involving the splitting off of HCl and the addition of NH3. 3. The rate of the splitting off of HCl depends on the nature of the substituent in the alkylthio group, increasing along the series CH3S
Databáze:	OpenAIRE
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