| Autor: |
S. Pradat, S. Aiache, J.-F. Pognat, J.-P. Kantelip, Jean-Marc Aiache, Nang Luu Si |
| Rok vydání: |
1983 |
| Předmět: |
|
| Zdroj: |
International Journal of Pharmaceutics. 16:241-251 |
| ISSN: |
0378-5173 |
| DOI: |
10.1016/0378-5173(83)90060-1 |
| Popis: |
The present study illustrates the importance of bioavailability testing whenever two active ingredients are combined in the same formulation in order to be administered simultaneously. The negative influence of the major spasmolytic drug, tiemonium, on the absorption of aspirin was demonstrated in the dog. This activity is so important that it was logical to suppose that this effect would be the same in man. In order to remove this effect, a special formulation was designed in which the two ingredients were released one after the other. Even so, an initial experiment in man gave unexpected results which were shown in an in vitro study to be due to extraneous factors connected with the preparation of the tablets. The importance of such in vitro investigations in avoiding hasty interpretation of in vivo findings is thus once again demonstrated. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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