| Popis: |
The compounds of the quinazoline family belong to the nitrogen-containing heterocyclics; the core structure represents various biological activities, and many natural compounds are also associated with quinazoline moiety. The tautomeric effect makes the molecule more reactive and facilitates a wide spectrum of activity. The quinazolinone ring is stable for oxidation, reduction, and hydrolysis reactions. The positions, such as 2, 6, and 8, are very much important to study the structure-activity relationship, which makes the quinazolinone and its derivatives one of the emerging privileged structures of pharmacophore. This review attempts to magnify the great potential of quinazoline and quinazolinone scaffolds in synthetic medicinal chemistry. This study may accelerate the designing process of the scaffold moiety. Moreover, this study provides opportunities fora number of therapeutically viable clinical candidates. The present review enlightened the structural activity relationship (SAR) study, which helps in improvement as well as generating further bioactive target-oriented compounds. |
