Synthesis of 9-(hexane-1,6-diol-3-yl)purines, a novel series of acyclic nucleoside analogs and antiviral evaluation

Autor:	Emile Bisagni, Michel Legraverend, Hassane Boumchita
Rok vydání:	1990
Předmět:	Purine Nucleoside analogue Stereochemistry Organic Chemistry Diol Primary alcohol Chloride In vitro chemistry.chemical_compound chemistry medicine Purine metabolism Curtius rearrangement medicine.drug
Zdroj:	Journal of Heterocyclic Chemistry. 27:1801-1804
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570270652
Popis:	New acyclic purine nucleoside analogs lacking the C(3′)C(4′) bond, have been prepared from 4-aminocyclohexene and evaluated for antiviral activity. A new synthesis of 4-aminocyclohexene from cyclohex-3-ene-1-carbonyl chloride is also reported via a Curtius reaction. None of the two compounds exhibited any antiviral activity in vitro against HSV-1, HCMV and HIV-1.
Databáze:	OpenAIRE
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