Progestogen Use and Risk of Breast Cancer
| Autor: | Régine Sitruk-Ware, Pierre Mauvais-Jarvis, Geneviève Plu-Bureau, Jean-Christophe Thalabard, G. Monique Lê |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Oncology
Gynecology medicine.medical_specialty education.field_of_study Progestogen medicine.drug_class business.industry Proportional hazards model medicine.medical_treatment Population medicine.disease Lower risk Breast cancer Internal medicine medicine Breast disease skin and connective tissue diseases business education Progestin Cohort study |
| Zdroj: | Hormonal Carcinogenesis II ISBN: 9781461275060 |
| DOI: | 10.1007/978-1-4612-2332-0_43 |
| Popis: | The role of progestins in the etiology of breast cancer (BC) remains unclear. Controversial results have been reported regarding the effects of progestins on the breast epithelial tissue and in epidemiological studies. In the late seventies, progestins were known to counteract the effects of estrogens, both at the target level and at the hypothalamopituitary level. We hypothesized that chronic administration of progestins, particularly 19-nortestosterone derivatives, at levels which exert an antigonadotropic effect, could reduce the risk of breast cancer. To investigate the role of chronic progestin use on the risk of breast cancer, a cohort study including 1150 premenopausal French women (aged 20–50) diagnosed with benign breast disease was carried out over a 10-year period. The analysis was performed using the Poisson regression and Cox proportional hazards models. The use of 19-nortestosterone derivatives was found to be significantly associated with a lower risk of breast cancer than that in untreated women (RR 0.48, 95% CI 0.25–0.90). In addition, there was a significant linear relationship between the duration of use and the decrease in the breast cancer risk (p for trend = 0.02). Our results suggest that progestin use was not associated with increased breast cancer risk in this population of women with benign breast disease. Furthermore, they suggest that some types of progestins might have a beneficial effect on the risk of breast cancer. |
| Databáze: | OpenAIRE |
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