The effect of an alpha-adrenergic receptor blocking drug on histamine sensitivity in bronchial asthma

Autor:	G.R. Petrie, J. Gaddie, J.S. Legge, K.N.V. Palmer
Rok vydání:	1972
Předmět:	Pulmonary and Respiratory Medicine Blocking drug Adrenergic receptor business.industry Pharmacology medicine.disease chemistry.chemical_compound Basal (phylogenetics) Blood pressure chemistry medicine Bronchoconstriction medicine.symptom business Receptor Histamine Asthma
Zdroj:	British Journal of Diseases of the Chest. 66:141-146
ISSN:	0007-0971
DOI:	10.1016/0007-0971(72)90020-4
Popis:	Histamine induced bronchoconstriction was significantly reduced in 6 patients with extrinsic bronchial asthma by thymoxamine, a specific α-adrenergic 3 . Mean pulse rate and blood pressure in 6 asthmatic patients after intravenous thymoxamine (0 · 2 μg/kg) Mean Mean pulse rate blood pressure Basal 77 124 79 Immediate 81 118 76 5 min 80 119 77 10 min 80 120 81 15 min 80 117 79 30 min 80 117 78 60 min 77 119 81 receptor blocking drug. This study suggests that there are α-adrenergic receptors in the bronchial muscle of asthmatics, and that histamine sensitivity in asthma is due to hypersensitivity of these receptors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9f39bd2a0ae3fccf0fc21021ee82b830 https://doi.org/10.1016/0007-0971(72)90020-4 Zobrazit plný text záznamu