High-intensity interval training with probiotic supplementation decreases gene expression of NF-κβ and CXCL2 in small intestine of rats with steatosis
| Autor: | Saba Mohammadi, Fatemeh Rostamkhani, Shahin Riyahi Malayeri, Hossein Shirvani |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
biology business.industry Fatty liver biology.organism_classification medicine.disease Small intestine Proinflammatory cytokine law.invention Jejunum Probiotic medicine.anatomical_structure Endocrinology Lactobacillus rhamnosus law Internal medicine medicine Orthopedics and Sports Medicine Steatosis business High-intensity interval training |
| Zdroj: | Sport Sciences for Health. 18:491-497 |
| ISSN: | 1825-1234 1824-7490 |
| DOI: | 10.1007/s11332-021-00829-5 |
| Popis: | The aim of this study was to investigate the effects of high-intensity interval training (HIIT) with probiotic supplementation (Lactobacillus rhamnosus GG) on gene expression of NF-κβ and CXCL2 in small intestine of rats with hepatic steatosis (induced by tetracycline). Forty male Wistar rats (200 ± 20 g) were randomly divided into five groups of (n = 8 in each group): healthy control (HC), hepatic steatosis (HS), HS + HIIT, HS + probiotic (Pro) 5. HS + HIIT + Pro. Tetracycline was gavage at a dose of 140 mg/kg, for 7 days, to induce hepatic steatosis. The HIIT performed 5 sessions per week for 5 weeks on the rodent treadmill. Probiotic groups received 109 CFU/ml of Lactobacillus rhamnosus GG by oral gavage for 5 weeks (daily). ALT and AST were measured to confirm of HS. NF-κβ and CXCL2 genes were measured by Real-Time PCR in small intestine (jejunum). The results showed that there was a significant difference in gene expression of NF-κβ and CXCL2 (jejunum) between groups (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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