Les symptômes non-moteurs de la maladie de Parkinson de la physiopathologie au diagnostic précoce
| Autor: | M. Tir, P. Krystkowiak, Mickael Aubignat |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pediatrics medicine.medical_specialty Systemic disease Parkinson's disease Dementia with Lewy bodies business.industry Neurodegeneration Central nervous system Gastroenterology Rapid eye movement sleep Disease medicine.disease nervous system diseases 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Atrophy Internal Medicine medicine business 030217 neurology & neurosurgery |
| Zdroj: | La Revue de Médecine Interne. 42:251-257 |
| ISSN: | 0248-8663 |
| DOI: | 10.1016/j.revmed.2020.06.019 |
| Popis: | Parkinson's disease is the second most common neurodegenerative disease after Alzheimer's disease. The pathophysiology of Parkinson's disease is complex and imperfectly known. Primum movens is abnormal intra-neuronal accumulation of the protein α-synuclein, leading to metabolic disturbances and neurodegeneration. This abnormal accumulation of α-synuclein is also found in dementia with Lewy bodies and multiple system atrophy, which together with Parkinson's disease form the group of α-synucleinopathies. Well known by its motor signs (bradykinesia, rest tremor, cogwheel rigidity and gait disturbance), Parkinson's disease is above all a systemic disease composed of a myriad of non-motor symptoms (constipation, sense of smell disorders, rapid eye movement sleep behaviour disorders, genitourinary disorders…). These non-motor symptoms caused by accumulation and migration of α-synuclein deposits from the gut and the olfactory bulb to the central nervous system may precede motor signs by ten years and therefore be of interest for early diagnosis. Furthermore, non-motor symptoms have a poorer impact on quality of life than motor signs themselves. Therefore, understanding, recognition and management of non-motor symptoms are crucial in management of parkinsonian patient. In this paper, we offer an update on the main non-motor symptoms of Parkinson's disease, from their pathophysiology to their screening, ending with their management. |
| Databáze: | OpenAIRE |
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